Non-monotonic neural growth functions suggest cathodic action potential blocking underlies human anodic dominance.

Evidence

In few cases, input/output growth functions were non-monotonic, showing a decrease in response amplitude with increases in level. Similar non-monotonic functions have already been observed at the level of the auditory nerve (Miller et al. 1998 ). They may reflect the blocking of action potentials along the nerve fibers (Frijns et al. 1996 ) and, therefore, remain a possible candidate explanation for the higher efficiency of anodic stimulation at suprathreshold levels in humans. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272 (#expands, via linked claim)

Categorization

• XREF: connects to: Action potential blocking for cathodic stimuli would produce non-monotonic neural growth patterns. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2277; Action-potential blocking along nerve fibers may explain anodic stimulation advantage at higher levels — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272; Never degeneration of neural peripheral processes may explain human anodic stimulation preference (+5 more)

Broader Connections

• Action-potential blocking along nerve fibers may explain anodic stimulation advantage at higher levels #expands (0.98) — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272
• Non-monotonic neural responses may come from action potential blocking along nerve fibers #corroborates (0.96)
• Action potential blocking for cathodic stimuli would produce non-monotonic neural growth patterns. #corroborates (0.95) — Dijk, Pim van, Physiology, Psychoacoustics and…, 2277
• Non-monotonic growth curves may reflect action potential blocking along nerve fibers #corroborates (0.95)
• Cathodic action potentials may block centrally at high current, explaining polarity effects #expands (0.94)
• Cathodic current pulses produce larger neural responses than anodic ones #complicates (0.85) — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272
• Never degeneration of neural peripheral processes may explain human anodic stimulation preference #complicates (0.82)
• Degenerated nerve processes make anodic stimulation more effective #complicates (0.80) — Dijk, Pim van, Physiology, Psychoacoustics and…, 2273