Action potential blocking can make louder cochlear implant stimuli evoke smaller responses
Evidence
In few cases, input/output growth functions were non-monotonic, showing a decrease in response amplitude with increases in level. Similar non-monotonic functions have already been observed at the level of the auditory nerve (Miller et al. 1998 ). They may reflect the blocking of action potentials along the nerve fibers (Frijns et al. 1996 ) and, therefore, remain a possible candidate explanation for the higher efficiency of anodic stimulation at suprathreshold levels in humans. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2324
Categorization
Category: Causal Relationships
- XREF: Connects to neural-firing/refractory dynamics and to broader auditory-nerve physiology material on response saturation and adaptation.
Related
- Action-potential blocking along nerve fibers may explain anodic stimulation advantage at higher levels (similarity 0.88)
- Non-monotonic neural responses may come from action potential blocking along nerve fibers (similarity 0.87)
- Cochlear implant input-output functions can be non-monotonic at high levels (similarity 0.83)
- Action potential blocking for cathodic stimuli would produce non-monotonic neural growth patterns. (similarity 0.83)
- Cochlear implant growth functions can behave non-monotonically near the top of the dynamic range (similarity 0.82)
- At suprathreshold levels louder electrical pulses can sometimes evoke smaller neural responses (similarity 0.82)
- Cathodic pulses produce larger cochlear implant responses than anodic pulses across pulse shapes (similarity 0.81)
- High-level cathodic stimulation can block action potential propagation centrally on auditory nerve fibers (similarity 0.81)
- Cochlear region and stimulation intensity systematically change human eCAP component parameters (similarity 0.81)
- Anodic stimulation is more effective in human implant users but less effective in animals (similarity 0.80)
- Electrical cochlear stimulation produces faster, larger neural responses than acoustic stimulation (similarity 0.80)
- Human cochlear-region differences alter electrically evoked compound action potential timing and width (similarity 0.80)
- At high current a cathodic pulse can block its own action potentials centrally. (similarity 0.79)
- Degenerated nerve processes make anodic stimulation more effective (similarity 0.79)
- Cathodic pulses are more efficient in animals but anodic pulses in humans (similarity 0.79)