Non-monotonic neural responses may come from action potential blocking along nerve fibers

Evidence

In few cases, input/output growth functions were non-monotonic, showing a decrease in response amplitude with increases in level. Similar non-monotonic functions have already been observed at the level of the auditory nerve (Miller et al. 1998 ). They may reflect the blocking of action potentials along the nerve fibers (Frijns et al. 1996 ) and, therefore, remain a possible candidate explanation for the higher efficiency of anodic stimulation at suprathreshold levels in humans. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272

Categorization

Category: Causal Relationships

Related

• Action-potential blocking along nerve fibers may explain anodic stimulation advantage at higher levels (similarity 0.96)
• Action potential blocking for cathodic stimuli would produce non-monotonic neural growth patterns. (similarity 0.88)
• Action potential blocking can make louder cochlear implant stimuli evoke smaller responses (similarity 0.87)
• High-level cathodic stimulation can block action potential propagation centrally on auditory nerve fibers (similarity 0.85)
• At suprathreshold levels louder electrical pulses can sometimes evoke smaller neural responses (similarity 0.83)
• Different auditory nerve fiber types have distinct response thresholds. (similarity 0.81)
• Auditory nerve fibers skip cycles, uncoupling spike timing from firing rate (similarity 0.81)
• At high current a cathodic pulse can block its own action potentials centrally. (similarity 0.80)
• Nerve degeneration or central blocking may explain anodic pulse dominance (similarity 0.80)
• Brainstem firing rate depends on absolute frequency, unlike the auditory nerve (similarity 0.79)
• Neurons can convert stimulus frequency directly into firing rate at the brainstem (similarity 0.79)