High-level cathodic stimulation can block action potential propagation centrally on auditory nerve fibers

Evidence

This model predicts that cathodic stimulation should elicit action potentials at the periphery of the neurons but that above a certain current level, the propagation of these action potentials may be blocked by the hyperpolarization produced more centrally on the fibers. This blocking was not observed in computer simulations using anodic stimuli because action potentials were in this case elicited at a more central locus on the fibers. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2272

Categorization

• QUESTION: Whether this conduction block was actually observed in the guinea pig IC data is a question the paper tests with non-monotonic growth functions.