Deconvolution of compound responses reveals two firing components invisible in raw waveforms
Evidence
Obviously, there are multiple differences in experimental settings and biology between the guinea pig and human, which may contribute to different CDLD outcomes. Among others, cause of deafness, cochlear anatomy, duration of deafness, and rate of neural degeneration differ, and there is awake vs. anaesthetized state, chronic vs. acute cochlear implantation, and long vs. short electrode array. Taking these differences into account, a few characteristics appeared to be quite robust across species and experimental setting. Importantly, the deconvolution of the eCAP revealed two separate firing components, which could not easily be detected from the eCAP waveforms themselves. The ratio of the components and the latency of the early component came out as potential markers to assess the condition of the auditory nerve. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2445
Categorization
Category: Causal Relationships
Related
- Electrically stimulated auditory nerve firing decomposes into two components detectable by deconvolution (similarity 0.94)
- Deconvolution reveals firing components invisible in raw eCAP waveforms (similarity 0.93)
- Deconvolution of electrically evoked CAPs can reveal neural health of the auditory nerve. (similarity 0.89)
- Deconvolution can recover firing-discharge timing from macro compound responses (similarity 0.88)
- Neural degeneration shifts eCAP firing-component scaling and latency in measurable ways. (similarity 0.88)
- Deconvolving the eCAP reveals two separate auditory nerve firing components. (similarity 0.86)
- Deconvolved nerve-response parameters depend heavily on the assumed unit response waveform (similarity 0.84)
- The second CDLD peak reflects repeated firing of the same auditory neurons (similarity 0.81)
- Auditory nerve degeneration measurably shifts electrically evoked firing patterns (similarity 0.81)
- Neural degeneration cannot explain why anodic stimulation suits humans but cathodic suits animals (similarity 0.79)
- Electrically evoked auditory nerve responses fit Gaussian rather than gamma latency distributions (similarity 0.78)
- Auditory nerve degeneration shortens spike latency and enlarges the second discharge peak (similarity 0.78)