Deconvolution of electrically evoked CAPs can reveal neural health of the auditory nerve.
Evidence
A few studies addressed the inverse problem, i.e. predicting the firing probability by deconvolution of acoustically evoked CAPs with a unit response (Elberling 1976a ; Charlet de Sauvage et al. 1987 ). To our knowledge no study investigated the inverse problem for eCAPs. In this study, we perform a deconvolution of eCAPs to examine CDLDs, presuming that they could provide information about the neural status of the auditory periphery. It has been shown that the eCAP in a guinea pig exhibits differences in its morphology depending on the neural health of the auditory nerve (Ramekers et al. 2014 , 2015 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 2389
Categorization
Category: Causal Relationships
- QUESTION: The relation between eCAP morphology and neural status is asserted but the mechanism is underexplained in this excerpt — worth pursuing.
Related
- Deconvolution can recover firing-discharge timing from macro compound responses (similarity 0.91)
- Electrically stimulated auditory nerve firing decomposes into two components detectable by deconvolution (similarity 0.90)
- Deconvolution of compound responses reveals two firing components invisible in raw waveforms (similarity 0.89)
- Deconvolution reveals firing components invisible in raw eCAP waveforms (similarity 0.87)
- Neural degeneration shifts eCAP firing-component scaling and latency in measurable ways. (similarity 0.86)
- Deconvolving the eCAP reveals two separate auditory nerve firing components. (similarity 0.86)
- Deconvolved nerve-response parameters depend heavily on the assumed unit response waveform (similarity 0.82)
- Auditory nerve degeneration measurably shifts electrically evoked firing patterns (similarity 0.79)