Auditory nerve degeneration shortens spike latency and enlarges the second discharge peak

Evidence

Figure 2 shows eCAP and CDLD examples for NH (a), 2WD (b) and 6WD animals (c). In each animal the deconvolution of the recorded eCAPs resulted in CDLDs with a fast rising peak, typically narrow (< 0.5 ms width), in most cases followed by a shoulder-shaped component or a second peak. In those cases the CDLD could be well fitted with the two-component GMM (Eq. 5 ), remaining single-peak cases (8 % of all CDLDs) could be well fitted with a single Gaussian. Figure 3 and Table 1 show group averages of CDLD parameters. Two variables significantly varied with group (i.e., with degeneration of the auditory nerve): μ1 and a2 /a1 (p < 0.05; rmANOVA with stimulation intensity as within factor, and group as between factor). With more nerve degeneration (6WD vs. 2WD and NH) the peak latency μ1 was shorter and a2 /a1 was larger. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2422

Categorization

• XREF: Connects to cochlear-implant neural survival literature and to the wider theme of spiral ganglion degeneration in sensorineural hearing loss.