Deconvolution can recover firing-discharge timing from macro compound responses

Evidence

A few studies addressed the inverse problem, i.e. predicting the firing probability by deconvolution of acoustically evoked CAPs with a unit response (Elberling 1976a ; Charlet de Sauvage et al. 1987 ). To our knowledge no study investigated the inverse problem for eCAPs. In this study, we perform a deconvolution of eCAPs to examine CDLDs, presuming that they could provide information about the neural status of the auditory periphery. It has been shown that the eCAP in a guinea pig exhibits differences in its morphology depending on the neural health of the auditory nerve (Ramekers et al. 2014 , 2015 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 2389

Categorization

• QUESTION: Conviction question: at what signal-to-noise floor does deconvolution of a 1.7 ms eCAP window stop being geometrically recoverable?