Tinnitus patients lack the normal task-related DMN deactivation seen in controls
Evidence
Our study is novel in the sense that it specifically assesses the influence of performing a task on the scale of brain networks as a whole. Specifically in patients with tinnitus, the DMN does not clearly show a task-effect, which in contrast is clearly present in controls. This observation enhances the hypothesis that subjects with tinnitus cannot get the ‘rest’ that is necessary for a healthy life. In conclusion, we attribute the pattern of reduced connectivity in the DMN to the unremitting engaging effect of the tinnitus percept. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2756
Categorization
Category: Factual Claims
- XREF: Connects to rest-state vs task-state brain dynamics literature and tinnitus pathophysiological models.
Related
- Chronic tinnitus prevents the brain from entering the resting state normally. (similarity 0.94)
- Tinnitus patients show reduced default mode network connectivity and a blunted task effect. (similarity 0.91)
- Tinnitus reduces default mode network activity by blocking mind-wandering (similarity 0.88)
- Task-subtraction fMRI paradigms cancel out tinnitus-related brain activity (similarity 0.85)
- A dysfunctional default-mode network links tinnitus with autism (similarity 0.84)
- Tinnitus patients show reduced functional connectivity in the precuneus region (similarity 0.84)
- Whether tinnitus causes or results from network changes is unknown (similarity 0.83)
- Tinnitus alters memory, attention, and emotion networks, with unknown causality (similarity 0.83)
- Resting-state fMRI reveals connectivity differences in numerous brain regions in tinnitus. (similarity 0.82)
- Tinnitus affects 5-10 percent of people with CNS mechanisms largely unknown (similarity 0.82)
- Tinnitus involves central nervous system mechanisms and remains poorly understood (similarity 0.81)
- fMRI measures slow metabolic changes and is noisy, complicating auditory research (similarity 0.80)
- Task-related fMRI subtraction can erase the very activity it aims to measure. (similarity 0.80)
- The default mode network may mediate internal sound perception across disorders (similarity 0.79)
- Tinnitus affects 5-10 percent of the population yet its causes remain largely unknown (similarity 0.79)