The default mode network may mediate internal sound perception across disorders

Evidence

This DMN has been previously implicated in other diseases such as Alzheimer’s disease. Lower functional connectivity scores in the DMN were found in an Alzheimer’s disease group when compared to normal groups (Binnewijzend et al. 2012 ). In contrast, results of resting-state data-analysis in schizophrenia have been variable (Greicius 2008 ). Schizophrenia is regarded as a large cluster of profound neuropsychiatric symptoms. A subtype of patients (also) experience phantom perception of sounds. One interpretation is that, since the DMN is different between groups in previous work and ours, the DMN somehow plays a role in ‘hearing’ internally generated sound (whether it is meaningful like in patients with schizophrenia or meaningless like tinnitus). — Dijk, Pim van, Physiology, Psychoacoustics and…, 2755

Categorization

Category: Causal Relationships

• QUESTION: DMN’s role in phantom sound perception across schizophrenia and tinnitus invites further investigation.

Related

• The default mode network may mediate perception of internally generated sound. (similarity 0.97)
• The default mode network strengthens when the mind wanders and underlies self-understanding. (similarity 0.92)
• A dysfunctional default-mode network links tinnitus with autism (similarity 0.84)
• Tinnitus reduces default mode network activity by blocking mind-wandering (similarity 0.84)
• Tinnitus patients show reduced default mode network connectivity and a blunted task effect. (similarity 0.82)
• Chronic tinnitus prevents the brain from entering the resting state normally. (similarity 0.80)
• Tinnitus patients show reduced functional connectivity in the precuneus region (similarity 0.80)
• Tinnitus alters memory, attention, and emotion networks, with unknown causality (similarity 0.80)
• Tinnitus patients lack the normal task-related DMN deactivation seen in controls (similarity 0.79)
• Whether tinnitus causes or results from network changes is unknown (similarity 0.79)