Tinnitus patients show reduced functional connectivity in the precuneus region

Evidence

Figure 3 shows the areas where the subject groups differ significantly are almost if not completely adjacent, indicating the potential relevance of the two spatial networks in tinnitus. Fig. 3 Group differences within two neural networks. The red-yellow colours indicate the significant differences in the network representing a visual area and the cingulate gyrus (see Fig. 2e ), and the blue-purple colours indicate the differences in the default-mode network (Fig. 2a ). These areas are remarkably adjacent, corresponding to the left and right (pre)cuneus. This area shows significantly reduced functional connectivity in patients compared to controls in both networks Fig. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2742

This area shows significantly reduced functional connectivity in patients compared to controls in both networks A total of ten networks were identified as neural in origin (Fig. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2729

The results from these analyses indicated that several networks behaved differently in controls than in subjects with tinnitus. Most notably it identified the default mode network (DMN), roughly encompassed by two distinct but similar networks in the data … In both the DMN and the latter component, there are adjacent voxels that show a clear and significant group difference (p < 0.001 for each of the maps, corresponding to a F-value of 12.71). When looking at the map strength, a proxy for functional connectivity, patients consistently show decreased functional connectivity (panels B and F). … The pattern of reduced connectivity is also clearly visible as a decreased power in the time-courses of the same voxels. … In all cases, the power is significantly lower in the patient groups. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2729

Categorization

• XREF: Connects to default-mode network literature and attentional/cognitive processing in hearing disorders from other chapters on auditory cognition.
• corroborated: 3 independent passages support this claim — Dijk, Pim van, Physiology, Psychoacoustics and…, 2742; Dijk, Pim van, Physiology, Psychoacoustics and…, 2729