Pulse polarity effects on neural response differ significantly across pulse shapes

Evidence

If neural degeneration had an effect on polarity sensitivity, we would expect the polarity effect to increase over time and to reach positive values when fibers are degenerated. This does not seem to be the case as the level difference between polarities rather tends to decrease right after deafening for several subjects and then to remain roughly constant. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2309 (#qualifies, via linked claim)

Categorization

• XREF: connects to: Cathodic action potentials may block centrally at high current, explaining polarity effects; Species differences in final nerve geometry may drive the polarity reversal; Asymmetric pulse shapes amplify polarity sensitivity beyond symmetric pulses — Dijk, Pim van, Physiology, Psychoacoustics and…, 2295 (+6 more)

Related

• Species differences in final nerve geometry may drive the polarity reversal (similarity 0.93)
• Cochlear implant input-output responses can reverse polarity preference at high levels (similarity 0.90)
• Neural degeneration does not increase polarity sensitivity following deafening (similarity 0.89)
• Asymmetric pulse shapes amplify polarity sensitivity beyond symmetric pulses (similarity 0.89)
• Neural degeneration alone does not explain polarity sensitivity differences in cochlear implants (similarity 0.89)
• Polarity effect magnitude is similar in guinea pigs and humans but reversed in sign (similarity 0.88)
• Neural degeneration does not alter CI pulse polarity sensitivity over time (similarity 0.87)
• Spiral ganglion degeneration does not progressively increase polarity sensitivity (similarity 0.87)
• Cathodic pulses produce larger cochlear implant responses than anodic pulses across pulse shapes (similarity 0.86)
• Cathodic action potentials may block centrally at high current, explaining polarity effects (similarity 0.85)
• Cathodic pulses evoke larger inferior colliculus responses than anodic pulses (similarity 0.85)
• Nerve degeneration or central blocking may explain anodic pulse dominance (similarity 0.85)
• Cathodic pulse superiority holds across all four tested pulse shapes (similarity 0.85)
• Neural degeneration over time does not flip cathodic-anodic stimulation efficiency in deafened guinea pigs (similarity 0.84)
• Never degeneration of neural peripheral processes may explain human anodic stimulation preference (similarity 0.84)

Broader Connections

• Pulse shapes require measurably different current levels to evoke equal neural responses #expands (0.78)
• Neural degeneration alone does not explain polarity sensitivity differences in cochlear implants #qualifies (0.75) — Dijk, Pim van, Physiology, Psychoacoustics and…, 2309
• Cochlear implant input-output responses can reverse polarity preference at high levels #expands (0.72)