Twin-peaked neural response latencies likely reflect repeated firing of the same fibres

Evidence

In most cases a2 /a1 is significant, in both guinea pigs and humans. This suggests either two subpopulations of fibres and/or neural elements (peripheral vs. central site of excitation) with different latencies and proportions, or repeated firings of the same neurons. The latter option is supported by the following arguments (see also in Ramekers et al. 2015 ). First, the interval between the two components, μ2 –μ1 , is about 0.5 ms, which is around the absolute refractory period estimated from masker-probe responses. Second, the N2 –N1 interval of the eCAP waveform has been found to correlate with recovery measures (Ramekers et al. 2015 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 2435

Categorization

Category: Causal Relationships

Related

• The nerve’s two latency components reflect neurons firing twice, not two fiber populations (similarity 0.88)
• Electrically evoked compound action potentials show two peaks consistent with neural refractory repriming (similarity 0.87)
• The second CDLD peak reflects repeated firing of the same auditory neurons (similarity 0.85)