Electrically evoked compound action potentials show two peaks consistent with neural refractory repriming

Evidence

In most cases a2 /a1 is significant, in both guinea pigs and humans. This suggests either two subpopulations of fibres and/or neural elements (peripheral vs. central site of excitation) with different latencies and proportions, or repeated firings of the same neurons. The latter option is supported by the following arguments (see also in Ramekers et al. 2015 ). First, the interval between the two components, μ2 –μ1 , is about 0.5 ms, which is around the absolute refractory period estimated from masker-probe responses. Second, the N2 –N1 interval of the eCAP waveform has been found to correlate with recovery measures (Ramekers et al. 2015 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 2435

Categorization

• DEFINE: Explains what a2/a1, the ratio of two CDLD components, means physiologically: two fibre subpopulations or repeated firing separated by the absolute refractory period.