Low-frequency receptor potentials drive oscillating calcium levels that modulate cochlear-amplifier gain
Evidence
Patuzzi ( 2011 ) postulated that large, LF receptor potentials activate voltage-sensitive, L-type Ca2+ channels in the OHC membrane. This results in an increase of intracellular Ca2+ in OHCs. Ca2+ -induced Ca2+ release and -uptake mechanisms, with different time courses, can then cause slow, underdamped oscillations of OHC cytosolic Ca2+ concentrations, modulating the gain of the cochlear amplifier (Patuzzi 2011 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 3703
Categorization
- corroborated: 3 independent passages support this claim — Dijk, Pim van, Physiology, Psychoacoustics and…, 3703
- XREF: connects to: Calcium oscillations in outer hair cells drive the hearing Bounce; Low-frequency sound’s after-effects arise from calcium homeostasis in outer hair cells — Dijk, Pim van, Physiology, Psychoacoustics and…, 3701; The olivo-cochlear efferent system accelerates recovery from calcium-induced sensitivity changes. — Dijk, Pim van, Physiology, Psychoacoustics and…, 3744 (+1 more)
Broader Connections
- Low-frequency sound’s after-effects arise from calcium homeostasis in outer hair cells
#corroborates(0.85) — Dijk, Pim van, Physiology, Psychoacoustics and…, 3701 - The cochlea may regulate gain slowly rather than compress sound instantly
#expands(0.78) — Dijk, Pim van, Physiology, Psychoacoustics and…, 3628 - The olivo-cochlear efferent system accelerates recovery from calcium-induced sensitivity changes.
#complicates(0.72) — Dijk, Pim van, Physiology, Psychoacoustics and…, 3744