Sisomycin completely destroys cochlear hair cells and causes progressive neural degeneration
Evidence
The round window was gently pierced and a mixture of sisomycin at a concentration of 50 mg/ml was injected into the round window niche until the bulla was completely filled with the mixture. The animal was left so for 2 h and the sisomycin was then aspirated from the bulla. This sisomycin treatment is known from previous experiments (Cazals et al. 1983 ) to completely destroy cochlear hair cells and lead to progressive spiral ganglion cells degeneration over months. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2279
This sisomycin treatment is known from previous experiments (Cazals et al. 1983 ) to completely destroy cochlear hair cells and lead to progressive spiral ganglion cells degeneration over months. — Dijk, Pim van, Physiology, Psychoacoustics and…, 2284
Categorization
- DEFINE: Establishes sisomycin as a standard chemical method for deafening/exciting spiral ganglion degeneration in the guinea pig model.
- corroborated: 3 independent passages support this claim — Dijk, Pim van, Physiology, Psychoacoustics and…, 2279; Dijk, Pim van, Physiology, Psychoacoustics and…, 2284
- XREF: connects to: Cochlear neuropathy harms supra-threshold encoding because noise targets high-threshold auditory fibers — Dijk, Pim van, Physiology, Psychoacoustics and…, 5873
Broader Connections
- Cochlear neuropathy harms supra-threshold encoding because noise targets high-threshold auditory fibers
#expands(0.80) — Dijk, Pim van, Physiology, Psychoacoustics and…, 5873