Shuffled cross-train spike intervals reveal time-varying periodicity in auditory responses

Evidence

Analyses are based on normalized shuffled inter-spike-interval distributions derived from the VCN-unit spike trains (Fig. 2 ; Joris et al. 2006 ; Sayles et al. 2015 ). We computed the across -spike-train shuffled inter-spike-interval distribution in a short (30-ms duration) rectangular time window, slid in 5-ms steps through the 400-ms duration response. We refer to these time-varying inter-spike-interval distributions as correlograms . — Dijk, Pim van, Physiology, Psychoacoustics and…, 5039 (#corroborates, via linked claim)

A robust but implicit code for pitch exists in the AN in the form of an across-fiber pooled interspike interval (ISI) distribution (Cariani and Delgutte 1996a , 1996b ; Meddis and Hewitt 1991a , b ), which resembles the stimulus autocorrelation. An unsolved question is how and whether this implicit temporal representation is transformed into a more explicit representation. Following an early model (Licklider 1951 ), various autocorrelation-type schemes have been proposed, in which periodicity-tuning is generated by some combination of coincidence detection and a source of delay. It is generally assumed that such a computation is implemented at a brainstem level, where responses are temporally precise over a broad range of frequencies. However, recordings have not revealed convincing evidence for level-invariant, periodicity-tuned neurons or sources of delay that cover a sufficiently broad temporal range (Neuert et al. 2005 ; Sayles et al. 2013 ; Sayles and Winter 2008a , 2008b ; Verhey and Winter 2006 ; Wang and Delgutte 2012 ). — Dijk, Pim van, Physiology, Psychoacoustics and…, 4495 (#complicates, via linked claim)

Categorization

• XREF: connects to: Shuffled inter-spike-interval analysis captures time-varying periodicity in single neurons. — Dijk, Pim van, Physiology, Psychoacoustics and…, 5039; Correlograms track spike-train periodicity over time via sliding windows; Autocorrelation pitch schemes lack neural evidence for periodicity-tuned neurons — Dijk, Pim van, Physiology, Psychoacoustics and…, 4495 (+1 more)

Broader Connections

• Shuffled inter-spike-interval analysis captures time-varying periodicity in single neurons. #corroborates (0.92) — Dijk, Pim van, Physiology, Psychoacoustics and…, 5039
• Autocorrelation pitch schemes lack neural evidence for periodicity-tuned neurons #complicates (0.71) — Dijk, Pim van, Physiology, Psychoacoustics and…, 4495