Just intonation leaves many intervals audibly mistuned like the D-A fifth

Evidence

Just intonation is based purely on triads, where the frequencies of the triads C-E-G, G-B-D, and F-A-C have the ratio 4:5:6 and octaves are always tuned to 2:1. Unfortunately, with this method, many intervals are not in tune. For example, the interval D-A should have the ratio 1.5, but in this tuning it is 1.48, which is audibly mistuned. The Pythagorean tuning system has the greatest number of pure fifths and octaves. Unfortunately, the thirds are then mistuned. — Ville Pulkki, Matti Karjalainen, Communication Acoustics- An…, 1306