Hair-cell adaptation to sound arises from neurotransmitter pool depletion and recycling dynamics

Evidence

Here, g, A, and B are parameters of the model. Hence, the amount of released transmittal material at a time instant t corresponds to k(t) q(t) dt, where q(t) denotes the amount of transmittal material in the transmitter pool next to the membrane. The majority of the transmittal material returns from the cleft to the hair cell at the rate r c(t), while some of the material is lost in the cleft and from the system with the speed l c(t). This loss introduces an adaptation to the firing rate. Moreover, the returned transmittal material first spends some time in the reprocessing store before entering the transmitter pool again. The speed of transmittal material entering the pool corresponds to x w(t), where w(t) denotes the amount of transmittal material in the store. Additionally, the hair cell contains a factory producing the transmittal material at the speed y{m −q(t)}, where m = 1. — Ville Pulkki, Matti Karjalainen, Communication Acoustics- An…, 1644

Categorization

• DEFINE: Defines the Meddis hair-cell model: transmitter pool, cleft, reprocessing store, and factory, with loss-rate l providing adaptation.
• XREF: This is the Meddis hair-cell model, widely invoked in auditory modeling literature; connects to the autocorrelation pitch model that follows in 13.11.