Each additional ACE point raises risk of major adult diseases in graded fashion.
Evidence
The dose-response relationship — the finding that each additional ACE score point was associated with graded increases in virtually every major adverse health outcome — was the finding that made the study impossible to dismiss. It was not that people with adverse childhoods had somewhat elevated disease risk. It was that the relationship was linear and consistent across outcomes. Every additional point on the ACE score increased the risk of heart disease, cancer, liver disease, depression, substance abuse, suicide attempt, and early death in a graded, dose-dependent fashion. — , The Rod and the Child, 9506
Categorization
- XREF: This is the dose-response mechanism underpinning earlier claims in the series about the lifelong consequences of childhood physical punishment. — connects to: ACE dose-response effects strengthen with higher baseline adversity in other populations — , The Rod and the Child: A Global History…, 7085; High-ACE parents generate high-ACE environments for their children within a single practice — , The Rod and the Child: A Global History…, 7084; High ACE scores predict a 31-fold rise in lifetime suicide attempts — , The Rod and the Child: A Global History…, 10673
Related
- High ACE scores predict a 31-fold rise in lifetime suicide attempts (similarity 0.88)
- Childhood adversity dose predicts adult depression, alcoholism, and suicide attempts (similarity 0.85)
- ACE dose-response effects strengthen with higher baseline adversity in other populations (similarity 0.84)
- Six ACE categories are themselves outcomes of parents’ own high ACE scores. (similarity 0.82)
- High-ACE parents generate high-ACE environments for their children within a single practice (similarity 0.81)
- Small per-child risk increases still yield large population-level disease burdens (similarity 0.80)
Broader Connections
- High ACE scores predict a 31-fold rise in lifetime suicide attempts
#expands(0.75) — , The Rod and the Child, 10673