Unchecked synaptic strengthening would saturate the hippocampus and block new learning

Evidence

If the synapses, particularly those of the hippocampus, did nothing but reinforce themselves under the effects of LTP, they would all very quickly attain a maximal degree of efficacy, and it would then be impossible to encode any new information. — Catherine Malabou, What Should We Do with Our Brain?, 299

Categorization

• XREF: The saturation point undermines a purely ‘receive and strengthen’ model of the brain — supports plasticity as active re-formation beyond mere reinforcement.