Suppression tuning curves mirror inner-ear neurophysiological frequency selectivity

Evidence

There is substantial variability in the relative contribution of suppression to ANF responses (Fig. 5a ), similar to that observed with tone stimuli in the “fractional-response” metric (e.g., Miller et al. 1997 ). There is a group of fibers (both NH and HI) across the CF axis, which show no significant suppression ( ; Fig. 5a ). These are mainly, but not exclusively, of the high-spontaneous-rate class (≥ 18 spikes s‑1 ). HI fibers in the region of greatest damage (~ 2–5 kHz) tend to have reduced suppression. Plotting vs . CF-normalized 10-dB bandwidth, we find a significant correlation between broadened tuning and loss of suppression (Fig. 5b ). Considering only CFs > 2 kHz in this linear regression increased the variance explained from 9.1 to 18.4 %. — Dijk, Pim van, Physiology, Psychoacoustics and…, 3871 (#corroborates, via linked claim)

Categorization

• XREF: connects to: Broadened frequency tuning correlates with loss of suppression in auditory nerve fibers — Dijk, Pim van, Physiology, Psychoacoustics and…, 3871; Cochlear suppression is essential for coding complex sounds but poorly characterized in hearing loss; Human efferent reflex tuning spans about half an octave around the signal (+2 more)

Related

• Broadened frequency tuning correlates with loss of suppression in auditory nerve fibers (similarity 0.94)
• Human efferent reflex tuning spans about half an octave around the signal (similarity 0.93)
• Cochlear suppression is essential for coding complex sounds but poorly characterized in hearing loss (similarity 0.91)
• Noise damage degrades frequency separation more severely than sensitivity (similarity 0.88)
• Suppressor tones reveal tuning curves matching neural frequency selectivity (similarity 0.86)
• Suppressor tones that reduce SOAEs map the ear’s fine frequency selectivity (similarity 0.86)
• Conductive hearing loss shifts tuning curves upward without degrading frequency resolution. (similarity 0.84)
• Noise-induced hearing loss reduces neural suppression in proportion to tuning broadening (similarity 0.83)
• Noise-damaged cochleas keep low-side suppression normal while high-side thresholds rise (similarity 0.83)
• Higher auditory thresholds predict smaller low-side suppression only at high signal levels (similarity 0.83)
• Hearing loss reduces cochlear suppression and compressive nonlinearity together (similarity 0.83)
• Two-tone suppression reflects saturation of outer-hair-cell receptor currents. (similarity 0.82)
• Sensorineural hearing loss reduces contrast in F0-synchronized neural rates across frequency (similarity 0.81)
• Noise-induced hearing loss eliminates high-side suppression in some broadly tuned fibers (similarity 0.81)
• Psychoacoustic tuning curves directly reflect cochlear mechanical processing. (similarity 0.81)

Broader Connections

• Broadened frequency tuning correlates with loss of suppression in auditory nerve fibers #corroborates (0.88) — Dijk, Pim van, Physiology, Psychoacoustics and…, 3871
• Cochlear suppression is essential for coding complex sounds but poorly characterized in hearing loss #expands (0.75)