Suppression measured via Wiener kernels bundles together three distinct neural mechanisms

Evidence

Positively and negatively weighted vectors are interpreted as excitatory and suppressive influences, respectively (Rust et al. 2005 ; Schwartz et al. 2006 ; Sneary and Lewis 2007 ). However, mechanical suppression, adaptation, and refractory effects may all contribute to what we term “suppressive” influences. To determine statistical significance of each weighted vector, we re-computed h 2 from 20 different spike:train randomizations, conserving the first-order inter-spike-interval distribution. Based on this bootstrap distribution, weights were expressed as z-scores, and any vector with |z| > 3 and rank ≤ 20 was considered significant. — Dijk, Pim van, Physiology, Psychoacoustics and…, 3842

Categorization

• DEFINE: Defines what ‘suppressive influences’ means in this analysis — a conflation of mechanical suppression, adaptation, and refractoriness.
• QUESTION: Given that suppression conflates three mechanisms, how does noise-induced hearing loss preferentially affect one over the others?