Stem cell multipotence allows only limited differentiation

Evidence

Brain stem cells, for example, necessarily differentiate themselves into one or another type of cell present in the brain: neurons or glial cells. There is a certain amount of room for maneuvering in differentiation, which is exactly what is meant by multipotence, but it remains limited. Multipotent stem cells produce only a restricted number of cellular types. — Catherine Malabou, What Should We Do with Our Brain?, 289

Categorization

• DEFINE: Defines multipotence as bounded differentiation capacity — key for contrasting cell-types vs flexibility.
• XREF: connects to: Embryonic stem cells are totipotent while adult stem cells are merely multipotent or pluripotent — Catherine Malabou, What Should We Do with Our Brain?, 290; Adult stem cells can transdifferentiate into cell types beyond their tissue of origin. — Catherine Malabou, What Should We Do with Our Brain?, 64
• yield-rescued: below the book’s yield-target cutoff, included anyway for connecting to: Embryonic stem cells are totipotent while adult stem cells are merely multipotent or pluripotent — Catherine Malabou, What Should We Do with Our Brain?, 290; Adult stem cells can transdifferentiate into cell types beyond their tissue of origin. — Catherine Malabou, What Should We Do with Our Brain?, 64

Broader Connections

• Embryonic stem cells are totipotent while adult stem cells are merely multipotent or pluripotent #expands (0.92) — Catherine Malabou, What Should We Do with Our Brain?, 290
• Adult stem cells can transdifferentiate into cell types beyond their tissue of origin. #complicates (0.88) — Catherine Malabou, What Should We Do with Our Brain?, 64