Intense cochlear sound stimulation raises intracellular calcium in hair cells

Evidence

It has been shown, however, that intense sound stimulation of the cochlea in the isolated temporal bone preparation increases intracellular Ca2+ level of hair cells and supporting cells (Fridberger et al. 1998 ; Jacob et al. 2013 ). Acoustic injury consists of a plethora of structural and metabolic changes to the cochlea, with structural damage possibly masking more subtle (and possibly oscillating) metabolic changes of cochlear sensitivity caused by the rise of intracellular Ca2+ levels. — Dijk, Pim van, Physiology, Psychoacoustics and…, 3744